Background If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical - trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world's nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the (...) 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial's stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. (shrink)

We offer obeisances to Lord Śiva, guru of knowledge, lord of the dance, who purifies by the very utterance of his name, who transcends all dualities. May he grant us permission to argue with his devotees. May he also give us his blessings to convince them.Properly speaking, comparative philosophy does not lead toward the creation of a synthesis of philosophical traditions. What is being created is not a new theory but a different sort of philosopher. The goal of comparative philosophy (...) is learning a new language, a new way of talking. The comparative philosopher does not so much inhabit both of the standpoints represented by the traditions from which he draws as he comes to inhabit an.. (shrink)

This (by no means exhaustive) survey of Postman’s work reflects on his penetrating analyses of contemporary technology. He focused attention on the ways technology today, especially the television and the computer, inevitably change us. The essential questions he asks us to ask (and answer) are, How does technology affect us? Is it for good or ill? and Must we accept all technological advances? Postman recognized the current dominance and autonomy of technology as well as the concomitant dangers and consequently made (...) the case and the plea for the reassertion of human over technological values. (shrink)

En este trabajo se describe un nuevo dispositivo didáctico que estamos diseñando y completando, los Recorridos de Estudio e Investigación (REI), que quieren contribuir a crear secuencias de enseñanza-aprendizaje.

Xavier Zubiri arouses a growing interest as a philosopher. It is, however, well known that he has also treated theological themes; he was concerned especially with the theology of the eucharist. Zubiri was convinced that the most precise concept of the eucharistic transformation was not the «transubstantiation» but «transubstantivation» and «transactualisation». In exposing Zubiri's conviction we meet two fundamental concepts of his philosophy: substantivity and actuality . Yet, to understand adequately these two concepts, it is necessary, it would seem, to (...) start from another fondamental concept of Zubiri: the sentient intelligence . For this reason the article intends, in the first place, to present the Zubirian concept of sentient intelligence, substantivity and actuality, in order, thereafter, to expose the concept of the eucharistic transformation as transubstantivation and transactualisation. Zubiri says that he does not claim to say new things about the eucharist, but only to conceive in his own way the things said before. In agreement with him, the article tries to show that, if one starts from his concept of human intelligence as sentient intelligence, human intellection will be primarily «actuality», the real will be «substantivity», and the adequate concept of the eucharistic transformation will be «transubstantivati. (shrink)

Newborn screening involves a complex logistical process, which depends on the close cooperation of many professionals, such as midwives, laboratory technicians, general practitioners and pediatricians. These professionals may encounter moral problems in the process, which have not been systematically studied before. This study fills this gap. We conducted interviews with 36 professionals involved in NBS in the Netherlands and made an inventory of the moral problems they encounter, as well as of the ways in which they tend to respond to (...) them. The moral problems professionals encounter stem from interpersonal conflicts and intrapersonal conflicts. Given the complexity of the work of NBS professionals, the study suggests that the moral problems that occur on the work floor cannot easily be solved by means of offering better or more stringent policy guidelines. Rather, it should be appreciated that professionals contribute significantly to shaping the morality of NBS with the help of their daily choices, and they should be supported in carrying out this task—for example with the help of a moral training or regular multidisciplinary moral deliberation, facilitated by an ethicist. (shrink)

L'A. se penche sur la pensée de saint Thomas d'Aquin pour en lever les ambiguïtés apparentes, notamment au sujet de l'âme. Il définit cette dernière comme forme du corps mais elle subsiste en elle-même. Comprendre se fait sans organe corporel en la conversio ad phantasma. L'abstraction appréhende la forme pure et aussi l'essence avec la matière commune. La substance est à la fois individuelle et universelle. La conversio ad phantasma décrit l'abstraction initiale. L'A. définit ainsi aussi l'intelligere, la ratio et (...) l'intellectus en en levant les ambiguïtés. Saint Thomas d'Aquin passait facilement d'un ordre à l'autre, essentiel ou existentiel, parce que dans sa vision hiérarchique de l'univers chaque unité se transcende vers une unité ultérieure jusqu'à ce que Dieu soit atteint. (shrink)

Aeschylus' imagery has for some time now been discussed as a feature of his dramatic technique which does more than merely adorn his work. Lebeck, for example, has described how images articulate the Oresteia: The images of the Oresteia are not isolated units which can be examined separately. Each one is part of a larger whole: a system of kindred imagery. They are connected to one another by verbal similarity rather than verbal duplication. Formulaic repetition is rare, except in the (...) cases of single ‘key’ words; it is replaced by associative or reminiscent repetition. Such repetition may evoke several different passages, yet correspond exactly to none. Each occurrence adds a new element to those with which it is associated. Often this expansion will be a blend of two images previously separate, preserving features reminiscent of both. In this way the different systems of imagery are intricately interwoven. The significance of a recurrent image unfolds in successive stages, keeping time with the action of the drama. (shrink)