Background If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical - trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world's nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the (...) 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial's stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. (shrink)

John Locke claimed that: ‘We never finding, nor conceiving it possible, that two things of the same kind should exist in the same place at the same time, we rightly conclude that, whatever exists anywhere at any time excludes all of the same kind, and is there itself alone’. He argued that, otherwise, ‘The notions and names of identity and diversity would be in vain, and there could be no such distinctions of substances or anything else one from another’. More (...) recently Professor D. Wiggins has made a similar claim for similar reasons. I shall maintain that, even if we accept the general outline of the essentialist account of identity given by Wiggins in his book, the claim that two things of the same kind cannot be in the same place at the same time should be rejected, until better reasons are forthcoming. (shrink)

Heuristics of evolutionary biology dictate that phylogenetically older processes are inherently more stable and resilient to disruption than younger processes. On the grounds that non-declarative behaviour emerged long before declarative behaviour, Reber argues that implicit learning is supported by neural processes that are evolutionarily older than those supporting explicit learning. Reber suggested that implicit learning thus leads to performance that is more robust than explicit learning. Applying this evolutionary framework to motor performance, we examined whether implicit motor learning, relative to (...) explicit motor learning, conferred motor output that was resilient to physiological fatigue and durable over time. In Part One of the study a fatigued state was induced by a double Wingate Anaerobic test protocol. Fatigue had no affect on performance of participants in the implicit condition; whereas, performance of participants in the explicit condition deteriorated significantly. In Part Two of the study a convenience sample of participants was recalled following a one-year hiatus. In both the implicit and the explicit condition retention of performance was seen and, contrary to the findings in Part One, so was resilience to fatigue. The resilient performance in the explicit condition after one year may have resulted from forgetting or from consolidation of declarative knowledge as implicit memories. In either case, implicit processes were left to more effectively support motor performance. (shrink)

In an important recent article T. C. W. Stinton reaffirmed the case that in Aristotle's Poetics, ch. 13, has a wide range of application. I do not wish to dispute the general conclusion of what seems to me a masterly analysis of the question but simply to discuss two areas where Stinton's argument may be thought defective–the interpretation of the examples given by Aristotle in Poetics 13, 5 3all and 53a2O–1 and the problem of the contradiction between 13, 53a13–15 and (...) 14, 54a4–9. (shrink)

En este trabajo se describe un nuevo dispositivo didáctico que estamos diseñando y completando, los Recorridos de Estudio e Investigación (REI), que quieren contribuir a crear secuencias de enseñanza-aprendizaje.

This (by no means exhaustive) survey of Postman’s work reflects on his penetrating analyses of contemporary technology. He focused attention on the ways technology today, especially the television and the computer, inevitably change us. The essential questions he asks us to ask (and answer) are, How does technology affect us? Is it for good or ill? and Must we accept all technological advances? Postman recognized the current dominance and autonomy of technology as well as the concomitant dangers and consequently made (...) the case and the plea for the reassertion of human over technological values. (shrink)

If we are to act properly with regard to the natural world, to protect, preserve, conserve, manage or leave it alone, we need both appropriate knowledge of that world, and a sound foundation for values to guide our actions. The thesis of this paper is that scientific ecology, though some of its interpreters claim it as a 'post-modern' eco-friendly science, in fact, while perhaps not as guilty as other of its post-modern interpreters might claim of the worst excesses of 'modernism', (...) nonetheless does retain the underlying assumptions of modernism. (The 'jargon' will be further explained.) The thesis will be supported by methods drawn from phenomenology. Phenomenological enquiry can reveal and criticise the modernist assumptions, while traditional phenomenological notions, in particular Heidegger's notion of Dwelling and Merleau-Ponty's notion of the body subject, I shall suggest, might form a more eco-friendly framework for enquiring into the character of interactions within the natural world and the basis of values in those interactions. (shrink)

Power indices are commonly required to assign at least as much power to a player endowed with some given voting weight as to any player of the same game with smaller weight. This local monotonicity and a related global property however are frequently and for good reasons violated when indices take account of a priori unions amongst subsets of players (reflecting, e.g., ideological proximity). This paper introduces adaptations of the conventional monotonicity notions that are suitable for voting games with an (...) exogenous coalition structure. A taxonomy of old and new monotonicity concepts is provided, and different coalitional versions of the Banzhaf and Shapley–Shubik power indices are compared accordingly. (shrink)